2-[1,3-双(二甲基氨基)-2-亚丙基]丙二腈合成路线 （共 7 条）
反应条件
1.1: 98 percent / HCl(gas) / methanol / 10 h / 0 °C 2.1: NaH / tetrahydrofuran / 0 °C 2.2: tetrahydrofuran / 24 h / 20 °C 2.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
反应条件
hydrogenchloride in methanol T=0°C; 10 h;
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
参考文献
Granik, V. G.; Grizik, S. I.; Solov'eva, N. P.; Anisimova, O. S.; Sheinker, Yu. N.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, # 3 p. 613 - 617
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 3 p. 673 - 678
反应条件
1.1: 98 percent / HCl(gas) / methanol / 10 h / 0 °C
2.1: NaH / tetrahydrofuran / 0 °C
2.2: tetrahydrofuran / 24 h / 20 °C
2.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating
3.1: 99 percent / ethanol / 4.5 h / Heating
4.1: 73 percent / p-toluenesulfonic acid / toluene / 130 °C
View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
反应条件
1.1: 98 percent / HCl(gas) / methanol / 10 h / 0 °C
2.1: NaH / tetrahydrofuran / 0 °C
2.2: tetrahydrofuran / 24 h / 20 °C
2.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating
3.1: 99 percent / ethanol / 4.5 h / Heating
4.1: 45 percent / p-toluenesulfonic acid / toluene / 130 °C
View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
反应条件
ammonia
high pressure;
参考文献
Ershov, L. V.; Granik, V. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 5 p. 544 - 547
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 5 p. 646 - 649
