1-(5-氯-6-甲基吡嗪-2-基)-哌啶-4-羧酸合成路线 （共 2 条）
反应条件
1: With triethylamine in ethanol; water
T=170°C; 0.666667 h;
2: With lithium hydroxide in tetrahydrofuran; ethanol; water
T=20°C;
3: in tetrahydrofuran; ethanol; water
pH=1;
参考文献
ASTRAZENECA AB
Patent: WO2007/8146 A1, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/008146 A1
反应条件
potassium acetate; trifluoroacetic acid
T=120°C; 10 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/8146 A1, 2007 ;
Location in patent: Page/Page column 46 ;
WO 2007/008146 A1
