1-(苄氧基)-2-甲基丙烷-2-醇合成路线 （共 4 条）
反应条件
sodium hydroxide in water; toluene
T=100°C; 30 h;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BAKER-GLENN, Charles; CHAN, Bryan K.; DOTSON, Jennafer; ESTRADA, Anthony; HEFFRON, Timothy; LYSSIKATOS, Joseph; SWEENEY, Zachary Kevin
Patent: WO2013/164323 A1, 2013 ;
Location in patent: Page/Page column 44 ;
反应条件
1: toluene / 0.02 h / -78 °C
2: 2 N NaOH / methanol / 0.5 h / 60 °C
View Scheme
参考文献
Adam, Waldemar; Harrer, Heinrich M.; Treiber, Alexander
Journal of the American Chemical Society, 1994 , vol. 116, # 17 p. 7581 - 7587
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Chen, Xiangning; Hortelano, Edwin R.; Eliel, Ernest L.; Frye, Stephen V.
Journal of the American Chemical Society, 1992 , vol. 114, # 5 p. 1778 - 1784
参考文献
Leggetter,B.E.; Brown,R.K.
Canadian Journal of Chemistry, 1964 , vol. 42, p. 990 - 1004
