1,8-diazabicyclo[2.2.2.]octane in acetonitrile T=75°C; 4.5 h;

1.1: n-BuLi / tetrahydrofuran 2.1: Mg / tetrahydrofuran 2.2: 57.5 percent / PCl3 / tetrahydrofuran / 5 h / -15 - 20 °C 3.1: 64 percent / 1,8-diazabicyclo[2.2.2]octane / acetonitrile / 4.5 h / 75 °C View Scheme

1.1: Mg / tetrahydrofuran 1.2: 57.5 percent / PCl3 / tetrahydrofuran / 5 h / -15 - 20 °C 2.1: 64 percent / 1,8-diazabicyclo[2.2.2]octane / acetonitrile / 4.5 h / 75 °C View Scheme