1-环己基-6-氧代-1,6-二氢-3-吡啶羧酸甲酯合成路线 （共 3 条）
反应条件
N-bromosuccinmide; sodium hydride in methanol
T=120°C; 0.5 h;
参考文献
Adams, Jeff; Hardin, Alison; Vounatsos, Filisaty
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9895 - 9898
反应条件
in N,N-dimethyl-formamide
T=0°C; 5.5 h; Heating / reflux;
参考文献
Astellas Pharma Inc.; Wakunaga Pharmaceutical Co., Ltd.
Patent: WO2008/140066 A2, 2008 ;
Location in patent: Page/Page column 31 ;
WO 2008/140066 A2
反应条件
in methanol
16 h; Heating / reflux;
参考文献
AMGEN INC.
Patent: WO2007/62007 A1, 2007 ;
Location in patent: Page/Page column 150 ;
WO 2007/062007 A1
