1-(4-甲氧基-3-(3-甲氧基丙氧基)苯基)-3-甲基-丁基-1-酮合成路线 （共 3 条）
反应条件
in water; acetic acid; ethyl acetate
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/124550 A1, 2010 ;
US 20100124550 A1
反应条件
1: 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.75 h; Inert atmosphere;
2: N-methoxy-N,3-dimethylbutanamide in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
参考文献
Hanessian, Stephen; Chenard, Etienne
Organic Letters, 2012 , vol. 14, # 12 p. 3222 - 3225
反应条件
potassium hydroxide in toluene
T=22 - 40°C; 8 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/6532 A1, 2007 ;
Location in patent: Page/Page column 18 ;
