反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 5 min 2: 93 percent / n-Bu4NI / dimethylformamide / 24 h / 80 °C 3: 100 percent / Dibal-H / toluene / 2 h / -78 deg C -> 0 deg C 4: 95 percent / HCl(g) 5: 1.) Wang resin, Huenig's base, 2.) 3percent Pd(PPh3)4, 2M Na2CO3, 3.) Br2, pyridine / 1.) DMF, 40-50 deg C, 2.) DME, reflux, 3.) DMF, 80-90 deg C, 24 h View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 16 p. 2703 - 2706
