hydrogenchloride in 1,4-dioxane T=20°C; 2 h;

1: orthoacetic acid trimethyl ester With hydrogenchloride in water T=50°C; 1.5 h; 2: 4-(2-piperazin-1-yl-thiazol-4-yl)-benzoic acid in water; acetonitrile T=20°C; pH=5.5; 1.5 h; Aqueous acetate buffer; 3: With sodium cyanoborohydride in water; acetonitrile T=20°C; pH=5.5; 16 h; Aqueous acetate buffer;

1: 2-methoxyacetaldehyde dimethyl acetal With hydrogenchloride in water T=50°C; 1.5 h; 2: 4-(2-piperazin-1-yl-thiazol-4-yl)-benzoic acid With sodium acetate; acetic acid in water; acetonitrile T=20°C; pH=5.5; 1.5 h; 3: With sodium cyanoborohydride in water; acetonitrile T=20°C; 16 h;