反应条件
1.1: tert-butyllithium / tetrahydrofuran; pentane / 0.5 h / -78 °C
1.2: ZnCl2 / tetrahydrofuran; pentane / -78 - 20 °C
1.3: 91 percent / Pd(PPh3)4 / tetrahydrofuran; pentane / -20 - 5 °C
2.1: 99 percent / K2CO3 / methanol / 3 h
3.1: 85 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
4.2: 57 percent / HMPA / tetrahydrofuran; hexane / 22 h / -20 - -10 °C
5.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 0 °C
6.1: 87 percent / iPr2NEt; SO3*pyridine / CH2Cl2; dimethylsulfoxide / 2 h / 20 °C
View Scheme
参考文献
De Vicente, Javier; Huckins, John R.; Rychnovsky, Scott D.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 43 p. 7258 - 7262
