1,2-二氢-2-氧代-1'-甲基螺[5-溴-3H-吲哚-3,4'-哌啶]合成路线 （共 2 条）
反应条件
N-bromosuccinmide in methanol; acetonitrile
T=-5 - 0°C; 3.5 h;
参考文献
Bissantz, Caterina; Grundschober, Christophe; Masciadri, Raffaello; Ratni, Hasane; Roger-Evans, Mark; Schnider, Patrick
Patent: US2008/153861 A1, 2008 ;
Location in patent: Page/Page column 19-20 ;
US 20080153861 A1
反应条件
1: 5-bromo-1,3-dihydro-2H-indol-2-one With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride in tetrahydrofuran
T=-78 - 20°C; 48.5 h;
参考文献
Ye, Lianbao; Tian, Yuanxin; Li, Zhonghuang; Jin, Hong; Zhu, Zhengguang; Wan, Shanhe; Zhang, Junyan; Yu, Pengjiu; Zhang, Jiajie; Wu, Shuguang
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 370 - 375
