N-(4-(((2-氨基-3,4,5,6,7,8-六氢-4-氧代-5-((2'-脱氧尿苷-5-基)甲基)吡啶并[3,2-d]嘧啶-6-基)甲基)氨基)苯甲酰基)谷氨酸 5'-单磷酸酯合成路线 （共 6 条）
反应条件
1: 60 percent / H2, aq. HCl / PtO2 / ethanol / 3 h / 2172.02 Torr
2: 62 percent / NaHCO3 / dimethylformamide / 6 h / Ambient temperature
3: 1.) acetylacetone, Zn/Cu, 2.) NaOH / 1.) DMF, 50 to 55 deg C, 1 h, 2.) EtOH, 48 h
View Scheme
参考文献
Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717
反应条件
1: 78 percent / CsF / 3 h / Ambient temperature
2: Br2 / CCl4 / Heating; Irradiation
3: 62 percent / NaHCO3 / dimethylformamide / 6 h / Ambient temperature
4: 1.) acetylacetone, Zn/Cu, 2.) NaOH / 1.) DMF, 50 to 55 deg C, 1 h, 2.) EtOH, 48 h
View Scheme
参考文献
Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717
反应条件
1: Br2 / CCl4 / Heating; Irradiation
2: 62 percent / NaHCO3 / dimethylformamide / 6 h / Ambient temperature
3: 1.) acetylacetone, Zn/Cu, 2.) NaOH / 1.) DMF, 50 to 55 deg C, 1 h, 2.) EtOH, 48 h
View Scheme
参考文献
Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717
反应条件
1: 62 percent / NaHCO3 / dimethylformamide / 6 h / Ambient temperature
2: 1.) acetylacetone, Zn/Cu, 2.) NaOH / 1.) DMF, 50 to 55 deg C, 1 h, 2.) EtOH, 48 h
View Scheme
参考文献
Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717
反应条件
1: 62 percent / NaHCO3 / dimethylformamide / 6 h / Ambient temperature
2: 1.) acetylacetone, Zn/Cu, 2.) NaOH / 1.) DMF, 50 to 55 deg C, 1 h, 2.) EtOH, 48 h
View Scheme
参考文献
Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717
反应条件
sodium hydroxide; copper; acetylacetone; zinc
1.) DMF, 50 to 55 deg C, 1 h, 2.) EtOH, 48 h; Yield given. Multistep reaction;
参考文献
Srinivasan, Ananthachari; Amarnath, Venkataraman; Broom, Arthur D.; Zou, F. C.; Cheng, Yung-Chi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1710 - 1717
