sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene T=80°C; Buchwald-Hartwig amination reaction; 1 h; microwave irradiation;

1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 - -20 °C 1.2: tetrahydrofuran / 3 h / -78 - 20 °C 1.3: 61 percent / AcOH; H2SO4 / tetrahydrofuran / 0.08 h / 120 °C 2.1: 57 percent / NaOtBu / Pd2(dba)3; BINAP / toluene / 1 h / 80 °C / microwave irradiation View Scheme

1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 - -20 °C 1.2: tetrahydrofuran / 3 h / -78 - 20 °C 1.3: 61 percent / AcOH; H2SO4 / tetrahydrofuran / 0.08 h / 120 °C 2.1: 57 percent / NaOtBu / Pd2(dba)3; BINAP / toluene / 1 h / 80 °C / microwave irradiation View Scheme