4-(二乙氨基)苯基硼酸频哪醇酯合成路线 (共 3 条)
反应条件
sodium hydride in tetrahydrofuran; mineral oil
T=20°C;
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; JI, Jianguo
Patent: WO2012/167423 A1, 2012 ;
Location in patent: Page/Page column 35 ;
WO 2012/167423 A1
反应条件
1: 2-(4-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: ethyl iodide in N,N-dimethyl-formamide
T=0 - 20°C; 72 h;
参考文献
Irm LLC
Patent: US2009/75996 A1, 2009 ;
Location in patent: Page/Page column 33 ;
反应条件
1: 4-(N,N-diethylamino)-bromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane
T=20°C; 12 h; Inert atmosphere;
参考文献
Park, Byung Sun; El-deeb, Ibrahim M.; Yoo, Kyung Ho; Han, Dong Keun; Tae, Jin Sung; Lee, So Ha
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 11 p. 3629 - 3634