1-环己基-2-(2-吡啶)-乙酮合成路线 (共 3 条)
反应条件
1: 2-picoline With n-butyllithium in tetrahydrofuran
T=-78 - 20°C; 1 h;
2: N-methyl-N-methoxy cyclohexanecarboxamide in tetrahydrofuran
T=-78 - 20°C; 41 h;
参考文献
Eli Lilly and Company
Patent: US6353008 B1, 2002 ;
Location in patent: Page column 29 ;
US 6353008 B1
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; water
参考文献
Eli Lilly and Company
Patent: US6436964 B1, 2002 ;
US 6436964 B1
反应条件
diethyl ether; phenyllithium
Erwaermen der erhaltenen Reaktionsloesung mit Cyclohexancarbonsaeure-aethylester in Aether;
参考文献
Goldberg et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 4301
Full Text View citing articles Show Details
Tilford; Van Campen
Journal of the American Chemical Society, 1954 , vol. 76, p. 2431,2435, 2438
Journal of the American Chemical Society, 1957 , vol. 79, p. 6575