triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; diisopropylamine; palladium diacetate in water; acetonitrile T=60°C; Suzuki cross-coupling; 36 h;

triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; palladium diacetate; diisopropylamine in water; acetonitrile T=60°C; Suzuki coupling; 36 h; regioselective reaction;

1: 95 percent / N-iodosuccinimide; trifluoroacetic acid / acetonitrile / 15 h / 20 °C 2: 72 percent / tris(3-sulfonatophenyl)phosphane trisodium salt; diisopropylamine / Pd(OAc)2 / acetonitrile; H2O / 36 h / 60 °C View Scheme