1: 1-(mercaptomethyl)-cyclopropaneacetic acid With sodium methylate in methanol; dimethyl sulfoxide T=-5 - 0°C; 1 h; 2: (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate in methanol; water; dimethyl sulfoxide T=-5 - 20°C; 10.5 h; 3: N,N-dicyclohexylamine With sodium hydroxide; acetic acid Product distribution / selectivity; more than 3 stages;

1: 1-(mercaptomethyl)-cyclopropaneacetic acid With n-butyllithium in tetrahydrofuran; hexane T=-15°C; 0.5 h; 2: (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate in tetrahydrofuran; hexane 1 h; Product distribution / selectivity;