2-氯-3-甲基苯甲酸甲酯合成路线 (共 2 条)
反应条件
sulfuric acid
T=80°C; 3 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2181987 A1, 2010 ;
Location in patent: Page/Page column 97 ;
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water
T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420