4-氯-1H-吡咯并[2,3-b]吡啶-3-甲腈合成路线 （共 3 条）
反应条件
sodium hydride in tetrahydrofuran; mineral oil 3 h; Cooling with ice water;
参考文献
VERNALIS (R and D) LTD.
Patent: WO2008/25947 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
1: With thionyl chloride in dichloromethane
T=25°C; 4 h; Heating / reflux;
2: With sodium hydrogencarbonate in water
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12635 A2, 2008 ;
Location in patent: Page/Page column 91 ;
反应条件
sodium hydroxide in tetrahydrofuran
T=20°C; 1 h;
参考文献
ASTELLAS PHARMA INC.
Patent: WO2007/7919 A2, 2007 ;
Location in patent: Page/Page column 36 ;
WO 2007/007919 A2
