4-氯-1-[三(1-甲基乙基)硅酯]-1H-吡咯并[2,3-B]吡啶-5-甲腈合成路线 （共 1 条）
反应条件
1: 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine With sec.-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: p-toluenesulphonyl cyanide in tetrahydrofuran; hexane
T=20°C; 2 h;
3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
ASTELLAS PHARMA INC.
Patent: WO2007/7919 A2, 2007 ;
Location in patent: Page/Page column 46-47 ;
WO 2007/007919 A2
