sodium hydroxide; water in ethanol T=50°C; 2 h;

1: With benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in N,N-dimethyl-formamide T=60°C; 0.5 h; 2: With ammonia in water; N,N-dimethyl-formamide T=20°C; 1 h;

4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 72 h;

1: 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 18 h; Inert atmosphere; 2: methanol in dichloromethane 2 h;