2-(2-甲基-3-硝基苯基)-乙基]-二丙胺盐酸盐合成路线 （共 3 条）
反应条件
1.1: ethanol; sodium / tetrahydrofuran / 15 - 30 °C / Inert atmosphere 1.2: 25 - 30 °C 2.1: sodium hydroxide; water / toluene; methanol / 0 - 5 °C / pH 12 2.2: 15 °C 2.3: 25 - 70 °C / pH < 2 / Activated charcoal View Scheme
参考文献
PHARMATHEN S.A.; KOFTIS, Theoharis, V.; GEORGOPOULOU, Ioanna; SONI, Rohit, Ravikant; MANDALOU, Panagiota; ALEXANDRAKI, Elli
Patent: WO2011/72704 A1, 2011 ;
反应条件
1.1: ethanol; sodium / tetrahydrofuran / 15 - 30 °C / Inert atmosphere 1.2: 25 - 30 °C 2.1: sodium hydroxide; water / toluene; methanol / 0 - 5 °C / pH 12 2.2: 15 °C 2.3: 25 - 70 °C / pH < 2 / Activated charcoal 3.1: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 25 - 35 °C / 2059.6 - 3236.52 Torr / Sealed tube 3.2: 0 - 35 °C View Scheme
参考文献
PHARMATHEN S.A.; KOFTIS, Theoharis, V.; GEORGOPOULOU, Ioanna; SONI, Rohit, Ravikant; MANDALOU, Panagiota; ALEXANDRAKI, Elli
Patent: WO2011/72704 A1, 2011 ;
反应条件
1: oxalic acid diethyl ester With ethanol; sodium in tetrahydrofuran T=15 - 30°C; Inert atmosphere; 2: N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride in tetrahydrofuran T=25 - 30°C;
参考文献
PHARMATHEN S.A.; KOFTIS, Theoharis, V.; GEORGOPOULOU, Ioanna; SONI, Rohit, Ravikant; MANDALOU, Panagiota; ALEXANDRAKI, Elli
Patent: WO2011/72704 A1, 2011 ;
Location in patent: Page/Page column 6-7 ;
