N,5-二甲基-2-噻唑甲胺合成路线 （共 2 条）
反应条件
1: methylamine With titanium(IV) isopropylate in methanol
0.0833333 h;
2: 5-methyl-1,3-thiazole-2-carbaldehyde in methanol
1 - 2 h;
3: With sodium tetrahydroborate in methanol
T=0 - 20°C;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 85-86 ;
WO 2009/042694 A1
反应条件
1: With titanium(IV) isopropylate in methanol
Inert atmosphere;
2: With sodium tetrahydroborate
T=0 - 20°C;
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
Location in patent: Page/Page column 86 ;
WO 2012/054510 A1
