1: With hydrogenchloride; tert.-butylnitrite in tetrahydrofuran
T=0°C; 1 h;
2: With sodium azide in tetrahydrofuran; water
T=0 - 20°C;
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
1.1: 84 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
2.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
2.2: 72 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
1.1: 90 percent / Et3N / tetrahydrofuran / -15 - 20 °C
2.1: 92 percent / methanol / 0 - 20 °C
3.1: 84 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
4.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
4.2: 72 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
1.1: 92 percent / methanol / 0 - 20 °C
2.1: 84 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 72 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
