1: triphenyl-methyl-phosphonium iodide With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 2: 1,3-dihydro-3-hydroxy-7-methoxyisobenzofuran-1-one in tetrahydrofuran T=0 - 20°C; Wittig olefination; 3: methyl iodide in tetrahydrofuran T=20°C; 12 h;

triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in methanol T=50°C; Suzuki-Miyaura coupling; 10 h;

1: 82 percent / DBU / tetrahydrofuran / 24 h / 20 °C 2: 89 percent / pyridine / 0 - 20 °C 3: 91 percent / triethylamine / PdCl2(dppf)*CH2Cl2 / methanol / 10 h / 50 °C View Scheme

1: 89 percent / pyridine / 0 - 20 °C 2: 91 percent / triethylamine / PdCl2(dppf)*CH2Cl2 / methanol / 10 h / 50 °C View Scheme