1: With sodium hydroxide in methanol T=70°C; 2: With hydrogenchloride in methanol Heating;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: NaOEt / ethanol / Heating<br />2.1: NaOEt / ethanol / 0.5 h / 60 &deg;C<br />2.2: ethanol / Heating<br />3.1: NiCl₂*6H₂O; NaBH₄ / methanol / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: NaOEt / ethanol / Heating<br />2.1: NaOEt / ethanol / 0.5 h / 60 &deg;C<br />2.2: ethanol / Heating<br />3.1: NiCl₂*6H₂O; NaBH₄ / methanol / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11343078', constants.ctx, '0')">sodium tetrahydroborate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128171', constants.ctx, '0')">nickel dichloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=0 - 20&deg;C;&nbsp;<br /> &nbsp;