6-氯-3-硝基吡啶-2-醇合成路线 （共 8 条）
反应条件
sulfuric acid; sodium nitrite T=0°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 70 ;
WO 2009/027732 A1
反应条件
1: With ammonia in ethanol 2: With sulfuric acid; sodium nitrite 3: With water
参考文献
Angewandte Chemie - International Edition, , vol. 42, # 5 p. 535 - 539
反应条件
tin(ll) chloride in ethyl acetate T=16 - 80°C; 3.25 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 70-71 ;
WO 2009/027732 A1
反应条件
silver carbonate in toluene 336 h; Ambient temperature;
参考文献
Pomel; Rovera; Godard; Marsais; Queguiner
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1995 - 2005
参考文献
Ernst, Justin T.; Becerril, Jorge; Park, Hyung Soon; Yin, Hang; Hamilton, Andrew D.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 5 p. 535 - 539
反应条件
1: 75 percent / Ag2CO3 / toluene / Heating
2: 65 percent / Pd(PPh3)4 / toluene / Heating
View Scheme
参考文献
Estroff, Lara A.; Incarvito, Christopher D.; Hamilton, Andrew D.
Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 2 - 3
反应条件
silver carbonate in toluene
Heating;
参考文献
Estroff, Lara A.; Incarvito, Christopher D.; Hamilton, Andrew D.
Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 2 - 3
反应条件
1.1: Ag2CO3
2.1: [Pd(PPh3)4]
3.1: O3 / acetic acid
3.2: AgNO3; KOH
4.1: PTSA
5.1: H2 / Pd/C
View Scheme
参考文献
Ernst, Justin T.; Becerril, Jorge; Park, Hyung Soon; Yin, Hang; Hamilton, Andrew D.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 5 p. 535 - 539
