2-溴-5-氯吡啶-4-甲醛合成路线 （共 2 条）
反应条件
1: 2-Bromo-5-chloropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-70 - -5°C; 1.25 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-70°C; 1 h;
3: With sodium hydroxide; water in tetrahydrofuran
T=20°C;
参考文献
Bezencon, Olivier; Bur, Daniel; Corminboeuf, Olivier; Dube, Daniel; Grisostomi, Corinna; MacDonald, Dwight; McKay, Dan; Powell, David; Remen, Lubos; Richard-Bildstein, Sylvia; Scheigetz, John; Therien, Michel; Weller, Thomas
Patent: US2009/176823 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
toluene-4-sulfonic acid in methanol
T=20°C; 3 h; Heating / reflux;
参考文献
Bezencon, Olivier; Bur, Daniel; Corminboeuf, Olivier; Dube, Daniel; Grisostomi, Corinna; MacDonald, Dwight; McKay, Dan; Powell, David; Remen, Lubos; Richard-Bildstein, Sylvia; Scheigetz, John; Therien, Michel; Weller, Thomas
Patent: US2009/176823 A1, 2009 ;
Location in patent: Page/Page column 17 ;
