5-氯-4-二甲氧基甲基-2-(3-甲氧基-丙基)-吡啶合成路线 （共 2 条）
反应条件
1: 1-bromo-3-(methyloxy)propane With iodine; magnesium in tetrahydrofuran
Heating / reflux;
2: 2-bromo-5-chloropyridine-4-dimethoxymethylpyridine With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran
T=0 - 20°C; 2.5 h; Heating / reflux;
参考文献
Bezencon, Olivier; Bur, Daniel; Corminboeuf, Olivier; Dube, Daniel; Grisostomi, Corinna; MacDonald, Dwight; McKay, Dan; Powell, David; Remen, Lubos; Richard-Bildstein, Sylvia; Scheigetz, John; Therien, Michel; Weller, Thomas
Patent: US2009/176823 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With hydrogenchloride; water
T=80°C; 2 h;
2: With sodium hydroxide in water; ethyl acetate
T=0°C; pH=10;
参考文献
Bezencon, Olivier; Bur, Daniel; Corminboeuf, Olivier; Dube, Daniel; Grisostomi, Corinna; MacDonald, Dwight; McKay, Dan; Powell, David; Remen, Lubos; Richard-Bildstein, Sylvia; Scheigetz, John; Therien, Michel; Weller, Thomas
Patent: US2009/176823 A1, 2009 ;
Location in patent: Page/Page column 17 ;
