1: nitroacetic acid ethyl ester With titanium tetrachloride in tetrahydrofuran T=0°C; 0.0833333 h; 2: tetrahydro-pyran-4-one With 4-methyl-morpholine in tetrahydrofuran T=0 - 20°C; 20 h;

1: nitroacetic acid ethyl ester With titanium tetrachloride in tetrahydrofuran T=0°C; 0.0833333 h; 2: tetrahydro-pyran-4-one With 4-methyl-morpholine in tetrahydrofuran T=20°C; 18 h; Title compound not separated from byproducts;

1: With hydrogenchloride; hydrogen; nickel in ethanol; water P=2585.81 Torr; 18 h; Parr hydrogenation apparatus; 2: in water pH=8 - 9;