4,8-二甲氧基-2-喹啉羧酸钾合成路线 (共 1 条)
反应条件
1: 2-methoxy-phenylamine; dimethyl acetylenedicarboxylate in methanol
T=3 - 20°C;
2: With Eaton's reagent
T=49 - 53°C; 5 - 7.5 h;
3: methyl iodide With potassium carbonate in N,N-dimethyl-formamide
T=37°C; 1 h;
参考文献
MERCK and CO., INC.; BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2007/11809 A1, 2007 ;
Location in patent: Page/Page column 104-105 ;