1: 2-methyl-5-hydroxy-pyridine With n-butyllithium in tetrahydrofuran; hexane
T=-20 - 25°C; 1 h;
2: tetrahydro-pyran-4-one in tetrahydrofuran; hexane
T=-78 - 25°C; 20 h;
3: With acetic acid in tetrahydrofuran; hexane; water
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2007/10390 A1, 2007 ;
Location in patent: Page/Page column 27-28 ;
WO 2007/010390 A1
