2-丁基-1,2,3,4-四氢异喹啉合成路线 （共 10 条）
反应条件
1: With titanium(IV) isopropylate
T=75°C; 6 h;
2: With sodium tetrahydroborate in ethanol
T=20°C; 3 h;
参考文献
Kumpaty, Hephzibah J.; Bhattacharyya, Sukanta
Synthesis, 2005 , # 13 art. no. M07404SS, p. 2205 - 2209
反应条件
1: 1,2,3,4-Tetrahydro-isoquinoline With (acryloyloxymethyl)polystyrene in N,N-dimethyl-formamide
T=20°C; Solid phase reaction; Michael addition; 18 h;
2: 1-iodo-butane in N,N-dimethyl-formamide
T=60°C; Solid phase reaction; quaternization; 24 h;
3: With N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; Solid phase reaction; Hofmann elimination; 5 h;
参考文献
Brown, Angus R.; Rees, David C.; Rankovic, Zoran; Morphy, J. Richard
Journal of the American Chemical Society, 1997 , vol. 119, # 14 p. 3288 - 3295
反应条件
sodium tetrahydroborate; 2-chloropyridine hydrochloride in tetrahydrofuran
T=70°C; Alkylation; Reductive amination; 15 h;
参考文献
Perrio-Huard, Cecile; Aubert, Catherine; Lasne, Marie-Claire
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 3 p. 311 - 316
反应条件
benzenethiol sodium salt in acetonitrile; butanone
Heating;
参考文献
Manoharan, T. Samuel; Madyastha, K. Madhava; Singh, B. B.; Bhatnagar, S. P.; Weiss, Ulrich
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 5 - 11
反应条件
1: CHCl3 / Heating
2: 70 percent / sodium thiophenoxide / acetonitrile; butan-2-one / Heating
View Scheme
参考文献
Manoharan, T. Samuel; Madyastha, K. Madhava; Singh, B. B.; Bhatnagar, S. P.; Weiss, Ulrich
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 5 - 11
反应条件
1: 5 percent / sodium thiophenoxide / acetonitrile; butan-2-one / Heating
2: CHCl3 / Heating
3: 70 percent / sodium thiophenoxide / acetonitrile; butan-2-one / Heating
View Scheme
参考文献
Manoharan, T. Samuel; Madyastha, K. Madhava; Singh, B. B.; Bhatnagar, S. P.; Weiss, Ulrich
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 5 - 11
反应条件
2: LiAlH4
View Scheme
参考文献
Kitane, Said; Tshiamala, Kabula; Laude, Bernard; Vebrel, Joeel; Cerutti, Ernest
Tetrahedron, 1985 , vol. 41, # 18 p. 3737 - 3751
反应条件
lithium aluminium tetrahydride
Yield given. Yields of byproduct given;
参考文献
Kitane, Said; Tshiamala, Kabula; Laude, Bernard; Vebrel, Joeel; Cerutti, Ernest
Tetrahedron, 1985 , vol. 41, # 18 p. 3737 - 3751
反应条件
sodium tetrahydroborate; trifluorormethanesulfonic acid
1.) CH2Cl2, 2.) MeOH; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Pearson, William H.; Fang, Wen-kui
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 4960 - 4961
反应条件
Yield given. Multistep reaction;
参考文献
Morphy, J. Richard; Rankovic, Zoran; Rees, David C.
Tetrahedron Letters, 1996 , vol. 37, # 18 p. 3209 - 3212
