反应条件
1: SOCl2 / 3 h / Heating
2: 1.) Mg(OEt)2, CCl4 / 1.) EtOH, Et2O, reflux, 3 h, 2.) EtOH, Et2O, toluene, reflux, 3 h
3: 100 percent / 60percent aq. HOAc, H2SO4 / 7 h / Heating
4: 94 percent / H2 / 10percent Pd/C / methanol
5: 95 percent / glacial acetic acid
View Scheme
参考文献
Bandurco, Victor T.; Schwender, Charles F.; Bell, Stanley C.; Combs, Donald W.; Kanojia, Ramesh M.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1421 - 1426
