1: 72 percent / second generation Grubbs catalyst / toluene / 2 h / Heating 2: DIBAL-H / diethyl ether; hexane / 2 h / -78 °C 3: 52.9 mg / toluene / 3.5 h / Heating 4: TFA / CH2Cl2 / 1.17 h / 0 - 20 °C 5: LiOH; H2O / methanol; tetrahydrofuran / 60 h / 20 °C 6: 6.4 mg / DIPEA; BOPCl / toluene / 37 h / 85 °C 7: CH2Cl2 / 0.67 h / 20 °C 8: K2CO3; MeOH / 1.5 h / 20 °C 9: 2.9 mg / aq. cerium ammonium nitrate / acetonitrile / 1 h / -10 °C View Scheme