N,N,N-triisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran Sonogashira coupling; 48 h; Heating;

1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid / dichloromethane 2: sodium hydroxide / dimethyl sulfoxide 3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 70 °C / |Inert atmosphere View Scheme

1: sodium hydroxide / dimethyl sulfoxide 2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 70 °C / |Inert atmosphere View Scheme