4-溴-1,1-双(3-甲基噻吩-2-基)-1-丁醇合成路线 （共 4 条）
反应条件
1: 73 percent / H2SO4 / propan-2-ol 2: 61 percent / K2CO3; KI / acetone View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 20percent aq. H2SO4 / propan-2-ol / 3 h / Ambient temperature 2: 50 percent / KI, K2CO3 / acetone / 44 h / Ambient temperature 3: 12 M aq. NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 2-bromo-3-methyl-thiophene With n-butyllithium in diethyl ether
2: ethyl 4-bromobutanoate in diethyl ether
T=-70°C;
参考文献
Zheng, Jianbin; Wen, Ren; Luo, Xiaomin; Lin, Guoqiang; Zhang, Jiange; Xu, Linfeng; Guo, Lihe; Jiang, Hualiang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 225 - 227
反应条件
sulfuric acid in isopropyl alcohol
参考文献
Zheng, Jianbin; Wen, Ren; Luo, Xiaomin; Lin, Guoqiang; Zhang, Jiange; Xu, Linfeng; Guo, Lihe; Jiang, Hualiang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 225 - 227
