(S)-3-(Boc-氨基)-2-哌啶酮合成路线 （共 15 条）
反应条件
1: hydrogen; water; hydrogenchloride; 5 Pd/C / ethanol / 24 h 2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 18 h / 120 °C / |Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4678 - 4681
反应条件
hydrogenchloride in ethyl acetate T=0°C; 1 h;
参考文献
Yu, Kuo-Long; Rajakumar, G.; Srivastava, Lalit K.; Mishra, Ram K.; Johnson, Rodney L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1430 - 1436
反应条件
borane-THF in tetrahydrofuran T=0 - 25°C; 6.75 h;
参考文献
ABBOTT LABORATORIES
Patent: EP1428824 A1, 2004 ;
Location in patent: Page 44 ;
反应条件
1: 85 percent / LiHMDS / tetrahydrofuran / Ambient temperature 2: 100 percent / H2 / Pd/C / ethanol / 1551.4 Torr View Scheme
参考文献
Semple; Rowley; Brunck; Ha-Uong; Minami; Owens; Tamura; Goldman; Siev; Ardecky; Carpenter; Ge; Richard; Nolan; Hakanson; Tulinsky; Nutt; Ripka
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4531 - 4536
反应条件
lithium hexamethyldisilazane in tetrahydrofuran Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 23 p. 4531 - 4536
