3-甲氧基-4-硝基苯甲酰胺合成路线 （共 7 条）
反应条件
T=85°C; Hofmann rearrangement;
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; 19 h;
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2007/59905 A2, 2007 ;
Location in patent: Page/Page column 43 ;
WO 2007/059905 A2
反应条件
1: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 5 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr View Scheme
参考文献
Bartkovitz, David Joseph; Chu, Xin-Jie; Ding, Qingjie; Karnachi, Prabha Saba; Liu, Jin-Jun; So, Sung-Sau; Zhang, Jing; Zhang, Zhuming
Patent: US2012/46306 A1, 2012 ;
反应条件
triethylamine; trifluoroacetic anhydride in tetrahydrofuran 1.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/82901 A1, 2005 ;
Location in patent: Page/Page column 39 ;
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
T=0 - 20°C; 1 h;
2: With ammonia in tetrahydrofuran
T=0°C; 0.166667 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/103755 A2, 2007 ;
Location in patent: Page/Page column 48; 56 ;
WO 2007/103755 A1
反应条件
ammonia in tetrahydrofuran; 1,4-dioxane
T=0 - 20°C; 5 h;
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2007/59905 A2, 2007 ;
Location in patent: Page/Page column 43 ;
WO 2007/059905 A2
反应条件
T=85°C; Hofmann rearrangement;
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
