3-甲基-[1,1-联苯]-2-羧酸合成路线 （共 18 条）
反应条件
1: (i) N2O3, AcOH, Ac2O, (ii) /BRN= 969212/
2: aq. NaOH / ethane-1,2-diol
3: N2O3 / acetic acid
View Scheme
参考文献
Hoover,J.R.E. et al.
J. Med. Chem., 1964 , vol. 7, # 3 p. 245 - 251
反应条件
1: (i) N2O3, AcOH, Ac2O, (ii) /BRN= 969212/
2: aq. NaOH / ethane-1,2-diol
3: N2O3 / acetic acid
View Scheme
参考文献
Hoover,J.R.E. et al.
J. Med. Chem., 1964 , vol. 7, # 3 p. 245 - 251
反应条件
1: (CF3CO2)3Tl, aq. KI
2: Li, CuBr / diethyl ether; nitrobenzene
View Scheme
参考文献
Carruthers,W.; Pooranamoorthy,R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 2405 - 2409
反应条件
1: water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benozquinone / 1,1-dimethylpropan-1-ol / 12 h / 100 °C / Inert atmosphere
2: potassium hydroxide / ethylene glycol / 8 h / 100 °C
View Scheme
参考文献
Wasa, Masayuki; Chan, Kelvin S. L.; Yu, Jin-Quan
Chemistry Letters, 2011 , vol. 40, # 9 p. 1004 - 1006
反应条件
1: toluene / 28 h / 20 °C / Reflux
2: water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benozquinone / 1,1-dimethylpropan-1-ol / 12 h / 100 °C / Inert atmosphere
3: potassium hydroxide / ethylene glycol / 8 h / 100 °C
View Scheme
参考文献
Wasa, Masayuki; Chan, Kelvin S. L.; Yu, Jin-Quan
Chemistry Letters, 2011 , vol. 40, # 9 p. 1004 - 1006
反应条件
lithium; copper(I) bromide in diethyl ether; nitrobenzene
参考文献
Carruthers,W.; Pooranamoorthy,R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 2405 - 2409
参考文献
Haworth; Tinker
Journal of the Chemical Society, 1955 , p. 911,914
反应条件
methanesulfonic acid
T=50 - 60°C;
参考文献
Tilly, David; Samanta, Subhendu S.; Castanet, Anne-Sophie; De, Asish; Mortier, Jacques
European Journal of Organic Chemistry, 2006 , # 1 p. 174 - 182
