4-甲氧基-[1,1-联苯]-2-羧酸合成路线 （共 12 条）
反应条件
thionyl chloride T=79°C; Friedel-Crafts acylation; 6 h;
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 20 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 25 p. 9350 - 9353
反应条件
dipotassium hydrogenphosphate; oxygen; palladium diacetate; p-benozquinone in tert-butyl alcohol
T=100°C; P=22801.5 Torr; 24 h;
参考文献
Wang, Dong-Hui; Mei, Tian-Sheng; Yu, Jin-Quan
Journal of the American Chemical Society, 2008 , vol. 130, # 52 p. 17676 - 17677
反应条件
dipotassium hydrogenphosphate; silver carbonate; p-benozquinone; palladium diacetate in tert-butyl alcohol
T=120°C; 3 h;
参考文献
Giri, Ramesh; Maugel, Nathan; Li, Jiao-Jie; Wang, Dong-Hui; Breazzano, Steven P.; Saunders, Lindsey B.; Yu, Jin-Quan
Journal of the American Chemical Society, 2007 , vol. 129, # 12 p. 3510 - 3511
反应条件
sodium hydroxide in ethanol
T=78°C;
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C
2: sodium hydroxide / ethanol / 78 °C
View Scheme
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C
2: sodium hydroxide / ethanol / 78 °C
View Scheme
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
1: p-cymene / Pd-C
2: (i) aq. NaOH, (ii) KMnO4, aq. NaOH
View Scheme
参考文献
Ross,N.C.; Levine,R.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2341 - 2346
反应条件
1: Na, liq. NH3
2: p-cymene / Pd-C
3: (i) aq. NaOH, (ii) KMnO4, aq. NaOH
View Scheme
参考文献
Ross,N.C.; Levine,R.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2341 - 2346
参考文献
Hoover et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 245,249
