(2R,6S)-rel-2,6-二甲基-4-(2-甲基-3-苯基丙基)吗啉盐酸盐合成路线 （共 4 条）
反应条件
sulfuric acid in dichloromethane T=-5°C; Friedel Crafts Alkylation; 1 h;
参考文献
SYNTECO S.P.A.-PRODOTTI DI SINTESI PER L'INDUSTRIA CHIMICA E FARMACEUTICA
Patent: US2011/301346 A1, 2011 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: bepromoline hydrochloride With Friedel-Craft catalyst in dichloromethane T=-20°C; 2: 1,1-dimethylpropyl chloride in dichloromethane Friedel Crafts Alkylation; Reactivity (does not react);
参考文献
Galderma S.A.
Patent: EP1935889 A1, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
1: bepromoline hydrochloride With Friedel-Craft catalyst in dichloromethane 2: 1,1-dimethylpropyl chloride in dichloromethane T=-52 - -20°C; Friedel Crafts Alkylation; Product distribution / selectivity;
参考文献
Galderma S.A.
Patent: EP1935889 A1, 2008 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: bepromoline hydrochloride With Friedel-Craft catalyst in dichloromethane 2: 1,1-dimethylpropyl chloride in dichloromethane T=-52 - -20°C; Friedel Crafts Alkylation; Product distribution / selectivity;
参考文献
Galderma S.A.
Patent: EP1935889 A1, 2008 ;
Location in patent: Page/Page column 8-9 ;
