sodium hydride in tetrahydrofuran T=20°C; Alkylation;

ethanol; sodium ethanolate T=130 - 140°C; Erhitzen unter Druck;

T=90°C; Zersetzung.;

1.1: lithium N,N-diisopropylamide / hexane; tetrahydrofuran / 0.83 h / -75 °C 1.2: 100 percent / hexane; tetrahydrofuran; toluene / 0.5 h / -75 °C 2.1: 99 percent / 1M aq. HCl / 0.5 h / Heating View Scheme

1: With sodium hydride in tetrahydrofuran 2: With toluene-4-sulfonic acid in acetone