6-环丙基-3-甲基-异噁唑并[5,4-b]吡啶-4-羧酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran T=20°C; 1.5 h; 2: With hydrogenchloride in water pH=2;
参考文献
BASF SE; MICHROWSKA-PIANOWSKA, Anna Aleksandra; MAJOR, Julia; HUTZLER, Johannes; NEWTON, Trevor William; EVANS, Richard Roger; KREUZ, Klaus; GROssMANN, Klaus; SONG, Dschun; SIMON, Anja; WITSCHEL, Matthias; MOBERG, William Karl; PARRA RAPADO, Liliana; QU, Tao; STELZER, Frank; KRAUS, Helmut; SEITZ, Thomas; KLOET, Andree van der; REINGRUBER, Ruediger
Patent: WO2012/10633 A1, 2012 ;
Location in patent: Page/Page column 54-55 ;
反应条件
1.1: sodium; methanol / 0 - 20 °C / Reflux 1.2: pH 2 2.1: acetic acid / 2 h / Reflux 3.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C 3.2: pH 2 View Scheme
反应条件
1.1: acetic acid / 2 h / Reflux 2.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C 2.2: pH 2 View Scheme
反应条件
1: With sodium hydroxide in tetrahydrofuran
T=20°C; 1.5 h;
2: With hydrogenchloride in water
pH=2;
参考文献
BASF SE; MICHROWSKA-PIANOWSKA, Anna Aleksandra; MAJOR, Julia; HUTZLER, Johannes; NEWTON, Trevor William; EVANS, Richard Roger; KREUZ, Klaus; GROssMANN, Klaus; SONG, Dschun; SIMON, Anja; WITSCHEL, Matthias; MOBERG, William Karl; PARRA RAPADO, Liliana; QU, Tao; STELZER, Frank; KRAUS, Helmut; SEITZ, Thomas; KLOET, Andree van der; REINGRUBER, Ruediger
Patent: WO2012/10633 A1, 2012 ;
Location in patent: Page/Page column 54-55 ;
反应条件
1.1: sodium; methanol / 0 - 20 °C / Reflux
1.2: pH 2
2.1: acetic acid / 2 h / Reflux
3.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C
3.2: pH 2
View Scheme
参考文献
BASF SE; MICHROWSKA-PIANOWSKA, Anna Aleksandra; MAJOR, Julia; HUTZLER, Johannes; NEWTON, Trevor William; EVANS, Richard Roger; KREUZ, Klaus; GROssMANN, Klaus; SONG, Dschun; SIMON, Anja; WITSCHEL, Matthias; MOBERG, William Karl; PARRA RAPADO, Liliana; QU, Tao; STELZER, Frank; KRAUS, Helmut; SEITZ, Thomas; KLOET, Andree van der; REINGRUBER, Ruediger
Patent: WO2012/10633 A1, 2012 ;
反应条件
1.1: acetic acid / 2 h / Reflux
2.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C
2.2: pH 2
View Scheme
参考文献
BASF SE; MICHROWSKA-PIANOWSKA, Anna Aleksandra; MAJOR, Julia; HUTZLER, Johannes; NEWTON, Trevor William; EVANS, Richard Roger; KREUZ, Klaus; GROssMANN, Klaus; SONG, Dschun; SIMON, Anja; WITSCHEL, Matthias; MOBERG, William Karl; PARRA RAPADO, Liliana; QU, Tao; STELZER, Frank; KRAUS, Helmut; SEITZ, Thomas; KLOET, Andree van der; REINGRUBER, Ruediger
Patent: WO2012/10633 A1, 2012 ;
