2-氨基-4-甲氧基-3-甲基苯甲腈合成路线 （共 5 条）
反应条件
1: in tetrahydrofuran; diethyl ether T=0 - 55°C; 4 h; 2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether T=0°C; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2007/14926 A1, 2007 ;
Location in patent: Page/Page column 128-129 ;
反应条件
1: 2-amino-4-hydroxy-3-methylbenzonitrile With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Simmen, Kenneth Alan; De Kock, Herman Augustinus; Raboisson, Pierre Jean-Marie Bernard; Hu, Lili; Lindquist, Karin Charlotta; Lindstrom, Mats Stefan; Belfrage, Anna Karin Gertrud Linnea; Wahling, Horst Jurgen; Nilsson, Karl Magnus; Samuelsson, Bengt Bertil; Rosenquist, Asa Annica Kristina; Sahlberg, Sven Crister; Wallberg, Hans Kristian; Kahnberg, Pia Cecilia; Classon, Bjorn Olof
Patent: US2009/118312 A1, 2009 ;
Location in patent: Page/Page column 53 ;
反应条件
1: 2-amino-4-hydroxy-3-methylbenzonitrile With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2007/14926 A1, 2007 ;
Location in patent: Page/Page column 128 ;
反应条件
1: With sodium hydroxide; ethanol; water
8 h; Heating / reflux;
2: With water; citric acid
参考文献
Simmen, Kenneth Alan; De Kock, Herman Augustinus; Raboisson, Pierre Jean-Marie Bernard; Hu, Lili; Lindquist, Karin Charlotta; Lindstrom, Mats Stefan; Belfrage, Anna Karin Gertrud Linnea; Wahling, Horst Jurgen; Nilsson, Karl Magnus; Samuelsson, Bengt Bertil; Rosenquist, Asa Annica Kristina; Sahlberg, Sven Crister; Wallberg, Hans Kristian; Kahnberg, Pia Cecilia; Classon, Bjorn Olof
Patent: US2009/118312 A1, 2009 ;
Location in patent: Page/Page column 53 ;
反应条件
1: With sodium hydroxide; ethanol; water
8 h; Heating / reflux;
2: With water; citric acid
参考文献
Simmen, Kenneth Alan; De Kock, Herman Augustinus; Raboisson, Pierre Jean-Marie Bernard; Hu, Lili; Lindquist, Karin Charlotta; Lindstrom, Mats Stefan; Belfrage, Anna Karin Gertrud Linnea; Wahling, Horst Jurgen; Nilsson, Karl Magnus; Samuelsson, Bengt Bertil; Rosenquist, Asa Annica Kristina; Sahlberg, Sven Crister; Wallberg, Hans Kristian; Kahnberg, Pia Cecilia; Classon, Bjorn Olof
Patent: US2009/118312 A1, 2009 ;
Location in patent: Page/Page column 53 ;
