3-溴-5-(4,5-二氢-4,4-二甲基-2-噁唑)-吡啶合成路线 （共 5 条）
反应条件
zinc(II) chloride in chlorobenzene
48 h; Heating;
参考文献
Bonneau, Anne-Laure; Robert, Nicolas; Hoarau, Christophe; Baudoin, Olivier; Marsais, Francis
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 1 p. 175 - 183
反应条件
thionyl chloride
T=20°C; 16 h;
参考文献
Robert, Nicolas; Bonneau, Anne-Laure; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2006 , vol. 8, # 26 p. 6071 - 6074
反应条件
1: CH2Cl2 / 48 h / 0 - 20 °C
2: 70 percent / thionyl chloride / 16 h / 20 °C
View Scheme
参考文献
Robert, Nicolas; Bonneau, Anne-Laure; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2006 , vol. 8, # 26 p. 6071 - 6074
反应条件
1: thionyl chloride / 2 h / Heating
2: CH2Cl2 / 48 h / 0 - 20 °C
3: 70 percent / thionyl chloride / 16 h / 20 °C
View Scheme
参考文献
Robert, Nicolas; Bonneau, Anne-Laure; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2006 , vol. 8, # 26 p. 6071 - 6074
反应条件
1: 3-bromo-5-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridine With lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
2: With zinc(II) chloride in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 1 h;
3: iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether
Negishi coupling; 20 h; Heating;
参考文献
Robert, Nicolas; Bonneau, Anne-Laure; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2006 , vol. 8, # 26 p. 6071 - 6074
