反应条件
1: 1-(3,4-dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h; Cooling with ice/salt/water bath;
2: propyl bromide in N,N-dimethyl-formamide
T=20°C;
参考文献
DOV PHARMACEUTICAL, INC.
Patent: WO2007/16155 A2, 2007 ;
Location in patent: Page/Page column 64; 75-77 ;