反应条件
1: 1-(3,4-dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.333333 h;
2: 1-bromo-butane in N,N-dimethyl-formamide
T=20°C; 24 h;
3: With water in N,N-dimethyl-formamide
参考文献
DOV PHARMACEUTICAL, INC.
Patent: WO2007/14264 A2, 2007 ;
Location in patent: Page/Page column 53-54 ;