4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苄基溴合成路线 （共 13 条）
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide T=100°C; 10 h;
参考文献
Resek; Bhattacharya; Khorana
Journal of Organic Chemistry, 1993 , vol. 58, # 26 p. 7598 - 7601
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; 4 h;
参考文献
Nakashima, Hiroyuki; Hashimoto, Makoto; Sadakane, Yutaka; Tomohiro, Takenori; Hatanaka, Yasumaru
Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15092 - 15093
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=70°C; 3 h;
参考文献
Latli, Bachir; Morimoto, Hiromi; Williams, Philip G.; Casida, John E.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 3 p. 191 - 199
反应条件
trifluorormethanesulfonic acid
T=-40°C; 1 h;
参考文献
Nakashima, Hiroyuki; Hashimoto, Makoto; Sadakane, Yutaka; Tomohiro, Takenori; Hatanaka, Yasumaru
Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15092 - 15093
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
反应条件
1: 100 percent / NaBH4 / ethanol / 4 h / 20 °C
2: 100 percent / CBr4; Ph3P / CH2Cl2 / 4 h / 20 °C
View Scheme
参考文献
Nakashima, Hiroyuki; Hashimoto, Makoto; Sadakane, Yutaka; Tomohiro, Takenori; Hatanaka, Yasumaru
Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15092 - 15093
反应条件
1: 80 percent / TiCl4 / various solvent(s) / 1 h / 20 °C
2: 100 percent / NaBH4 / ethanol / 4 h / 20 °C
3: 100 percent / CBr4; Ph3P / CH2Cl2 / 4 h / 20 °C
View Scheme
参考文献
Nakashima, Hiroyuki; Hashimoto, Makoto; Sadakane, Yutaka; Tomohiro, Takenori; Hatanaka, Yasumaru
Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15092 - 15093
反应条件
1: hydroxylamine; pyridine / ethanol
2: pyridine
3: 76 percent / NH3
4: 59 percent / N-bromosuccinimide; AIBN
View Scheme
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
反应条件
1: pyridine
2: 76 percent / NH3
3: 59 percent / N-bromosuccinimide; AIBN
View Scheme
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
反应条件
1: 76 percent / NH3
2: 59 percent / N-bromosuccinimide; AIBN
View Scheme
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
