4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苄基溴合成路线 （共 13 条）
反应条件
1: 83 percent / n-BuLi
2: hydroxylamine; pyridine / ethanol
3: pyridine
4: 76 percent / NH3
5: 59 percent / N-bromosuccinimide; AIBN
View Scheme
参考文献
Riber, Ditte; Venkataramana, Musturi; Sanyal, Suparna; Duvold, Tore
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1503 - 1505
反应条件
1: 95 percent / cyanuric fluoride, pyridine / CH2Cl2 / 2 h / -20 - -10 °C
2: 84 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / Ambient temperature
3: 91 percent / CBr4, PPh3 / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Latli, Bachir; Morimoto, Hiromi; Williams, Philip G.; Casida, John E.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 3 p. 191 - 199
反应条件
1: 84 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / Ambient temperature
2: 91 percent / CBr4, PPh3 / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Latli, Bachir; Morimoto, Hiromi; Williams, Philip G.; Casida, John E.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 3 p. 191 - 199
