3,3-二甲基-3,4-二氢-1H-喹啉-2-酮合成路线 （共 22 条）
反应条件
copper(l) iodide; N-acetyl-glycine; potassium iodide; sodium hydroxide in tert-butyl alcohol
T=100°C; 24 h;
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
反应条件
sulfuric acid; hydrogen; acetic anhydride; palladium on activated charcoal in acetic acid
12 h; Ambient temperature;
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
反应条件
methoxybenzene; trifluoroacetic acid
T=65°C; 3 h; Inert atmosphere;
参考文献
Winter, Dana K.; Drouin, Alexandre; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2610 - 2618
反应条件
1: 100 percent / lithium hydroxide / methanol; H2O / 15 h / 0 °C
2: 53 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 32 h / 20 °C
3: hydrogen / Pd/C / methanol / atmospheric pressure
View Scheme
参考文献
Liu, Bin; Hu, Longqin
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3889 - 3899
反应条件
1: 53 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 32 h / 20 °C
2: hydrogen / Pd/C / methanol / atmospheric pressure
View Scheme
参考文献
Liu, Bin; Hu, Longqin
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3889 - 3899
反应条件
hydrogen; palladium on activated charcoal in methanol
atmospheric pressure;
参考文献
Liu, Bin; Hu, Longqin
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3889 - 3899
反应条件
1: 1-chloro-3,4-dihydro-3,3-dimethylquinolin-2(1H)-one in dichloromethane
T=-78°C; 4 h; UV-irradiationInert atmosphere;
2: methanol With potassium carbonate
T=20°C; 18 h; Inert atmosphere;
参考文献
Winter, Dana K.; Drouin, Alexandre; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2610 - 2618
反应条件
1: 35 percent / phosphorus pentaoxide / xylene / 2 h / Heating
2: 72 percent / acetic anhydride, conc. sulphuric acid, H2 / Pd/C / acetic acid / 12 h / Ambient temperature
View Scheme
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
反应条件
1: 82 percent / conc. nitric acid / H2O
2: 1.) thionyl chloride / 1.) THF, reflux, 2 h; 2.) ether, ice-cooling
3: 35 percent / phosphorus pentaoxide / xylene / 2 h / Heating
4: 72 percent / acetic anhydride, conc. sulphuric acid, H2 / Pd/C / acetic acid / 12 h / Ambient temperature
View Scheme
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
反应条件
1: 1.) thionyl chloride / 1.) THF, reflux, 2 h; 2.) ether, ice-cooling
2: 35 percent / phosphorus pentaoxide / xylene / 2 h / Heating
3: 72 percent / acetic anhydride, conc. sulphuric acid, H2 / Pd/C / acetic acid / 12 h / Ambient temperature
View Scheme
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
